Asthma in pregnancy: Contemporary management - PubMed
4 hours ago
- #pregnancy
- #healthcare
- #asthma
- Asthma affects 8-13% of pregnancies and is linked to adverse maternal and fetal outcomes.
- Uncontrolled asthma in pregnancy increases risks of preterm birth, hypertensive disorders, and impaired fetal growth.
- Key biological pathways include airway inflammation, oxidative stress, placental dysfunction, and maternal hypoxemia.
- Pregnancy-specific immunologic shifts, especially a Th2-predominant state, may exacerbate asthma activity.
- Modifiable contributors include viral infections, air pollution, obesity, allergic rhinitis, GERD, and sleep apnea.
- Management emphasizes proactive monitoring, symptom assessment, and controller therapy escalation.
- Contemporary strategies include anti-reliever therapy and maintenance-and-reliever therapy.
- Non-pharmacologic interventions are also highlighted for comprehensive asthma management.
- Future research areas include precision-guided asthma care and biologic therapies in pregnancy.