Inferring past demography and genetic adaptation in Spain using the GCAT cohort - PubMed
2 days ago
- #genetics
- #demography
- #adaptation
- Study analyzes 704 whole-genome sequences from the GCAT cohort to infer past demography and genetic adaptation in Spain.
- Iberian Peninsula's geographical position may have influenced distinct selective pressures and gene flow patterns compared to the rest of Europe.
- No clear evidence of 16th-century admixture related to the French diaspora during the Wars of Religion was found.
- Signals of North African admixture were detected, matching the Muslim period and Christian Reconquista.
- Novel top candidates for positive selection were identified, including genes associated with immunity and diet (UBL7, SMYD1, VAC14, FDFT1).
- Local ancestry deviation analysis revealed post-admixture selection in the MHCIII genomic region following Steppe ancestry admixture.
- The study was approved by relevant ethical review boards and declared no competing interests.