Stress-Induced ADGRL4 Orchestrates Tumor Progression and Metastasis by Inhibiting YAP1 Signaling and Activating Angiogenesis - PubMed
4 hours ago
- #YAP1 signaling
- #ADGRL4
- #tumor progression
- ADGRL4, a GPCR, is identified as a key regulator of tumor adaptation to stress.
- Stress induces ADGRL4 expression via the JNK-ATF2/c-Jun pathway.
- ADGRL4 limits tumor expansion but its loss accelerates tumor growth and metastasis.
- ADGRL4 activation suppresses YAP1 activity via cAMP-PKA signaling.
- Without ADGRL4, hyperactivated YAP1 forms a complex with β-catenin, driving tumor growth.
- ADGRL4 reduces chemosensitivity and promotes angiogenesis, increasing relapse risk.
- ADGRL4 acts as a stress sensor balancing tumor-suppressing and tumor-promoting states.