Identification of PANoptosis hub genes driving immune activation and tubulointerstitial injury in diabetic kidney disease by integrative bioinformatics and machine learning - PubMed
4 hours ago
- #Machine learning
- #PANoptosis
- #Diabetic kidney disease
- Diabetic kidney disease (DKD) is characterized by chronic inflammation and immune dysregulation.
- PANoptosis integrates pyroptosis, apoptosis, and necroptosis, playing a key role in inflammatory disorders, but its role in DKD was unclear.
- The study integrated multiple renal tubulointerstitial transcriptomic datasets to identify differentially expressed genes and functional enrichments.
- Six PANoptosis-related hub genes (YWHAH, PRKACB, PSMB9, FAS, GZMA, CASP1) were identified, correlating with immune-cell infiltration and renal function.
- A PANoptosis-related risk score (PRS) was developed, effectively discriminating DKD from controls and identifying high-risk subgroups.
- Regulatory network analysis revealed miRNA and transcription factor control over hub genes.
- Druggability profiling highlighted CASP1, FAS, PSMB9, and PRKACB as pharmacologically actionable targets.
- The study suggests PANoptosis as a unifying driver of tubulointerstitial injury in DKD, with hub genes serving as potential biomarkers and therapeutic targets.