Stem-like T cells in cancer immunotherapy: biology, regulation and therapeutic targeting - PubMed
3 hours ago
- #stem-like T cells
- #therapeutic targeting
- #cancer immunotherapy
- Stem-like CD8+ T cells (TPEX) have progenitor-like properties including self-renewal and multilineage differentiation.
- The abundance of TPEX cells correlates with improved clinical outcomes in various cancer immunotherapies.
- Specialized niche microenvironments sustain TPEX cells through chemokine signaling and antigen-presenting cell interactions.
- Core molecular circuitry balances self-renewal and effector differentiation via transcription factors and cytokines.
- Therapeutic strategies targeting TPEX cells aim to enhance immunotherapy efficacy and overcome resistance.
- Approaches include niche modulation, stem-like CAR-T engineering, and combinatorial therapies.