Association of Blood Eosinophil Counts with Expiratory Airflow Limitation: A Multi-Ethnicity Observational Study - PubMed
a day ago
- #eosinophil
- #Mendelian randomization
- #lung function
- Elevated blood eosinophil counts (BECs) are linked to lung function impairment across diverse populations.
- The study involved three cohorts: Hongtong, NHANES, and UK Biobank, with longitudinal data from UK Biobank.
- BECs showed inverse associations with FEV1, strongest in UK Biobank, with significant reductions per BEC increase.
- Higher baseline BECs predicted accelerated lung function decline, especially in males and smokers.
- Mendelian randomization supported a potential causal role of BECs in lung function deficits, with variations by ancestry.
- Findings suggest monitoring BECs in asymptomatic individuals could aid in personalized prevention strategies.