Bedside identification of subphenotypes in acute respiratory failure (PHIND): a multicentre, observational cohort study - PubMed
3 hours ago
- #precision medicine
- #biomarkers
- #ARDS subphenotypes
- The PHIND study prospectively identified two subphenotypes of ARDS (hyperinflammatory and hypoinflammatory) using a near-patient assay measuring IL-6, TNFR1, and plasma bicarbonate.
- 60-day mortality was significantly higher in the hyperinflammatory group (51%) compared to the hypoinflammatory group (28%), with an adjusted odds ratio of 2.7.
- The study involved 512 patients from UK and Irish ICUs and demonstrated the feasibility of rapid subphenotype identification for precision medicine in ARDS.