Association of Lp(a) with coronary plaque burden and high-risk plaque features: A meta-analysis of imaging studies - PubMed
5 hours ago
- #Lipoprotein(a)
- #Cardiovascular risk
- #Coronary plaque
- Lipoprotein(a) [Lp(a)] is a causal risk factor for cardiovascular disease.
- Meta-analysis of 16 studies (19,822 participants) shows high-risk Lp(a) levels significantly associated with coronary plaque presence (OR 1.53).
- Elevated Lp(a) linked to greater progression in percent atheroma volume (MD 4.31%).
- High-risk Lp(a) associated with increased low-attenuation plaque (LAP) presence (OR 1.92).
- Findings highlight Lp(a) as a driver of high-risk, rupture-prone plaques and a potential therapeutic target.