A20 restricted PDCoV release through negative regulation of PANoptosis - PubMed
4 hours ago
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- #PANoptosis
- #PDCoV
- A20 regulates PANoptosis during PDCoV infection, aiding antiviral defense.
- PDCoV induces PANoptosis in intestinal epithelial cells, facilitating viral particle release.
- A20 restricts PANoptosome assembly by degrading RIPK3 ubiquitin chains, limiting cell lysis.
- PDCoV-induced PANoptosis release is driven by osmotic imbalance from GSDMD and MLKL pore formation.
- Pharmacological inhibition of GSDMD and MLKL reduces viral dissemination and preserves epithelial barrier.
- The A20-PANoptosis axis is a potential target for antiviral intervention.