Panacis Quinquefolii Radix Polysaccharides Alleviate Depressive-Like Behaviors in Chronic Unpredictable Mild Stress-Induced Mice by Suppressing Complement C1Q/C3-Mediated Microglial Synaptic Pruning a
4 hours ago
- #gut-brain axis
- #microglia
- #antidepressant
- XYS1, a polysaccharide from American ginseng, alleviates depressive-like behaviors in mice induced by chronic unpredictable mild stress (CUMS).
- Mechanistically, XYS1 suppresses complement activation by downregulating C1Q in microglia and C3 in astrocytes, inhibiting microglial synaptic pruning.
- XYS1 preserves glutamatergic neuron density and excitatory synapses, and modulates gut microbiota by enriching Bacillota and reducing Bacteroidota.
- It reduces pro-inflammatory cytokines (TNF-α, IL-1β) and complement components while restoring anti-inflammatory IL-10, mitigating colonic and systemic inflammation.
- The antidepressant effects involve modulation of the C1Q/C3 pathway, inhibition of microglial-mediated synaptic pruning, and restoration of gut microbiota homeostasis.