Apigenin is a Potential Drug for Treating Ischemic Stroke. Association between Plasma Protein Genes and Ischemic Stroke: A Proteome-wide Mendelian Randomization Analysis and Experimental Study - PubMe
4 hours ago
- #mendelian-randomization
- #ischemic-stroke
- #apigenin
- Apigenin identified as a potential drug for treating ischemic stroke (IS).
- Mendelian randomization (MR) analysis linked 26 plasma proteins to IS risk, with 7 (Ppp1r14a, Stoml2, Lyve1, WISP1, IL5RA, Tfrc, Klrg2) serving as potential biomarkers.
- Molecular docking and dynamics simulations showed strong binding of TFRC with apigenin, metformin, vitamin K3, and estradiol.
- Key genes involved in IS development include Ppp1r14a, Stoml2, Lyve1, WISP1, IL5RA, Tfrc, and Klrg2.
- Further in vivo and in vitro studies needed to confirm apigenin's therapeutic effects targeting TFRC in IS treatment.