Circulating Biomarkers of Neurodegeneration and All-Cause and Dementia-Specific Mortality - PubMed
3 hours ago
- #biomarkers
- #mortality
- #neurodegeneration
- Blood-based biomarkers like GFAP and NfL are linked to higher risks of all-cause, dementia-specific, and cardiovascular mortality.
- The study involved a biracial cohort of 30,239 Black and White participants, with a mean follow-up of 11.1 years.
- GFAP showed the strongest association with dementia-specific mortality (HR 5.66), followed by NfL (HR 2.72).
- No significant associations were found between total tau and mortality outcomes.
- The findings highlight the potential of these biomarkers in clinical practice for assessing mortality risks.