Extrinsic lipids are absorbed and accumulate in colorectal cancer - PubMed
4 hours ago
- #microbiome
- #colorectal cancer
- #lipid metabolism
- Extrinsic lipids, including long-chain PUFAs like arachidonic acid, accumulate in colorectal cancer (CRC).
- Accumulation is more pronounced in right-sided tumors and observed in both human CRC patients and Apc1638N mouse models.
- CRC-specific fatty acid profiles are independent of sex, molecular subtypes, and disease onset timing.
- Absorption of fatty acids from the intestinal lumen into tumors was confirmed in pathogen-free Apc1638N mice.
- Germ-free Apc1638N mice developed fewer tumors and had increased survival, indicating microbiome influence.
- Inhibition of fatty acid import or β-oxidation reduces cancer cell proliferation.
- Findings suggest dietary fatty acids play a role in CRC cell proliferation and open potential therapeutic avenues targeting lipid absorption and microbiome interactions.