Aspirin use, lipoprotein(a), and calcific aortic valve disease: the Multi-ethnic Study of Atherosclerosis - PubMed
2 days ago
- #Lipoprotein(a)
- #Aspirin
- #Aortic Valve Disease
- Aspirin use is associated with a lower risk of incident aortic valve calcium (AVC) and severe aortic stenosis (AS) in individuals with high lipoprotein(a) [Lp(a)] levels.
- No significant association was found between aspirin use and AVC or AS risk in individuals with elevated LDL cholesterol (LDL-C) levels.
- The study included 6,598 participants from the Multi-Ethnic Study of Atherosclerosis (MESA), with a mean age of 62 years and 53% women.
- Regular aspirin use (≥3 days/week) was reported by 23% of participants.
- Over a median follow-up of 8.9 years, 8% developed AVC, and 1% developed severe AS over a median of 16.7 years.
- For participants with Lp(a) ≥75 mg/dL, aspirin use was associated with a 58% lower risk of AVC (HR 0.42) and a 98% lower risk of severe AS (HR 0.02) for Lp(a) ≥75 mg/dL.
- The study suggests aspirin may play a role in preventing AVC and AS in individuals with high Lp(a), but further confirmatory studies are needed.