Immune cells play a mediating role in the relationship between the gut microbiota and dementia: A Mendelian randomization study - PubMed
3 hours ago
- #immune cells
- #gut microbiota
- #dementia
- The study explores the mediating role of immune cells in the relationship between gut microbiota and dementia subtypes using Mendelian randomization.
- 37 gut microbiome species and 137 immune cell subsets showed potential causal effects with Alzheimer's disease, Frontotemporal dementia, Vascular dementia, and Parkinson's disease dementia.
- Specific immune cells, such as CD45RA + CD28- CD8+ T cells and CD19 on IgD- CD38dim B cells, mediate the effects of certain gut bacteria on Alzheimer's disease.
- CD4+ CD8+ T cells mediate the relationship between genus.Roseburia and Parkinson's disease dementia.
- Other immune cells mediate links between Coriobacteriales, Lactococcus, and Vascular dementia.
- The findings suggest that gut microbiome influences dementia pathogenesis through immune regulatory pathways.