NK cells promote cardiac cell death and regulate myelopoiesis in myocardial infarction - PubMed
3 hours ago
- #Myocardial infarction
- #NK cells
- #Cardiac remodeling
- NK cells are recruited to ischemic myocardium after acute myocardial infarction (MI) in mice via CCR2.
- Activated NK cells release granzyme B, leading to cardiomyocyte apoptosis and worsened cardiac remodeling and function.
- Deleting or depleting NK cells reduces cardiomyocyte death, inflammation, injury, and improves cardiac function.
- NK cell activation using anti-NKG2A antibody exacerbates ischemic heart failure.
- NK cells regulate bone marrow myelopoiesis through local GM-CSF production.
- A distinct NK cell signature is identified in early-stage human ischemic heart tissue.