Single-cell and spatial profiling reveal cDC2A-CXCL13+CD8+ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus - PubMed
3 hours ago
- #lichen planus
- #TNFRSF9
- #single-cell RNA sequencing
- Single-cell and spatial profiling reveal cDC2A-CXCL13+CD8+ T-epithelial cell crosstalk in lichen planus (LP).
- Elevated interferon (IFN) and cytotoxic signatures found in CXCL13+CD8+ T cells in cutaneous and mucosal LP.
- T cells expressing TNF and IFNG are spatially linked to epithelial cells, correlating with inflammation.
- cDC2A cells identified as key contributors, proximal to CXCL13+CD8+ T cells, and a major source of IL-15.
- CXCL13+CD8+ T cells express TNFRSF9 (4-1BB), enhancing cytotoxic responses in the skin.
- Study supported by Novartis, with no competing interests declared by remaining authors.