Role of astrocyte biomarker GFAP in early diagnosis and prognosis assessment of dementia: A comprehensive review - PubMed
3 hours ago
- #Biomarker
- #GFAP
- #Dementia
- Astrocytes play a crucial role in dementia by regulating cerebral blood flow, promoting myelin regeneration, and maintaining CNS homeostasis.
- Glial fibrillary acidic protein (GFAP) is a biomarker of reactive astrocytes and an emerging indicator for dementia diagnosis and prognosis.
- GFAP's role in early diagnosis and prognosis assessment spans various dementia types, including Alzheimer's disease (AD), vascular dementia (VaD), and frontotemporal dementia (FTD).
- Recent advances in GFAP detection technologies, such as SIMOA and Lumipulse, are highlighted, alongside discussions on plasma vs. CSF GFAP measurement differences.
- The review aims to enhance understanding of GFAP's clinical and research significance in dementia, supporting the development of improved diagnostics and therapies.