Sinominine alleviates pulmonary fibrosis by suppressing macrophage-to-myofibroblast transition via inhibition of the Frem1/NF-κB/IL-1β axis - PubMed
3 hours ago
- #Sinominine
- #Pulmonary Fibrosis
- #Macrophage Transition
- Sinominine (SIN) alleviates pulmonary fibrosis by inhibiting macrophage-to-myofibroblast transition (MMT).
- The study identifies Frem1 as a direct target of SIN, crucial for IL-1β-driven fibrosis.
- Frem1 activates the MyD88/NF-κB pathway, creating a positive feedback loop that amplifies IL-1β production.
- Genetic ablation of Frem1 and IL-1β stimulation confirmed its role in MMT.
- SIN's anti-fibrotic effects are mediated by suppressing the Frem1/NF-κB/IL-1β axis.
- The findings suggest a novel therapeutic mechanism for idiopathic pulmonary fibrosis (IPF).