Prospective observational study to assess the prognosis of patients with myeloproliferative neoplasms in Japan (MPN-15): results of baseline analysis - PubMed
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- #Myeloproliferative neoplasms
- #Japan
- #Prospective study
- Prospective observational study (MPN-15) conducted in Japan to assess prognosis of myeloproliferative neoplasms (MPNs).
- 1252 patients enrolled with polycythemia vera (PV), essential thrombocythemia (ET), prefibrotic primary myelofibrosis (pre-PMF), and fibrotic PMF.
- JAK2V617F mutations detected in 96.8% of PV patients and ~60% in other subtypes; CALR and MPL mutations more common in ET, pre-PMF, and fibrotic PMF.
- Chromosomal abnormalities and symptom burden highest in fibrotic PMF.
- Most PV and ET patients classified as high risk in thrombotic and survival risk stratification.
- Ruxolitinib used in 14% of PV and 34% of fibrotic PMF patients, with no serious adverse events reported.
- First large-scale prospective MPN registry in Japan; ongoing follow-up to provide insights into long-term outcomes and treatment optimization.