A single cell transcriptional profile of benign prostatic hyperplasia - PubMed
4 hours ago
- #inflammation
- #single-cell RNA-seq
- #BPH
- Single-cell RNA-sequencing was performed on prostate tissue from 15 BPH patients undergoing holmium laser enucleation.
- 16,234 cells were analyzed, revealing stromal, epithelial, and immune subgroups linked to inflammation.
- A rare luminal subgroup with a high stem cell signature was identified, suggesting a precursor state.
- Significant ligand-receptor interactions involving MIF were found between the luminal subgroup, fibroblasts, and macrophages.
- The study provides insights into inflammation-linked cell subgroups and potential therapeutic targets for BPH.