The potential of plant-derived exosome-like nanovesicles from Centella asiatica leaves (CA-PDENs) for anti-inflammation and prevention of UVB-induced photoaging - PubMed
3 hours ago
- #plant-derived nanovesicles
- #photoprotection
- #anti-inflammatory
- CA-PDENs are exosome-like nanovesicles isolated from Centella asiatica leaves using differential centrifugation and PEG precipitation.
- They exhibit strong early-phase anti-inflammatory effects by suppressing nitric oxide in LPS-stimulated RAW 264.7 macrophages.
- CA-PDENs show photoprotective properties, reducing ROS and collagen degradation in UVB-induced fibroblasts, and enhance wound closure.
- The nanovesicles demonstrate moderate antibacterial activity against Cutibacterium acnes and are non-cytotoxic with efficient cellular uptake.
- CA-PDENs contain metabolite biosynthesis enzymes and have potential as multifunctional ingredients for nanocosmetics against inflammation and photoaging.