Select Small Non-Coding RNAs Are Determinants of Survival in Older Adults - PubMed
4 hours ago
- #aging
- #longevity
- #non-coding RNA
- Study investigates small non-coding RNAs (smRNAs) as determinants of survival in older adults.
- Evaluated 828 smRNAs (687 miRNAs and 141 piRNAs) in plasma from 1,271 older adults (≥71 years).
- Predictive model combining smRNAs, clinical variables, and age achieved high accuracy (AUC 0.92 for 2-year survival).
- Nine piRNAs, reduced in longer-lived individuals, identified as potential therapeutic targets.
- Findings suggest circulating piRNAs and miRNAs as biomarkers and therapeutic targets for human longevity.
- Reduced piRNA biogenesis linked to doubled lifespan in C. elegans, supporting biological plausibility.