Autocrine SFRP2 (secreted frizzled related protein 2) enhances lung myofibroblast fibrogenic activity by suppressing PINK1-mediated mitophagy initiation - PubMed
3 days ago
- #WNT Signaling
- #Mitophagy
- #Idiopathic Pulmonary Fibrosis
- Autocrine SFRP2 enhances lung myofibroblast fibrogenic activity in idiopathic pulmonary fibrosis (IPF).
- SFRP2 suppresses PINK1-mediated mitophagy by activating FZD5-mediated non-canonical WNT-Ca2+ signaling.
- Therapeutic interventions like AAV6-shSfrp2, SFRP2-neutralizing antibody, or rapamycin reduce lung fibrosis in mouse models.
- The study identifies SFRP2-mitophagy axis as a key regulator of myofibroblast activation and a potential therapeutic target.