Comparative Effectiveness of Ivabradine Versus Digoxin in Patients With Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease: A Real-World Multicenter Cohort Study - PubMed
3 hours ago
- #chronic kidney disease
- #heart failure
- #ivabradine
- Study compares ivabradine and digoxin in HFrEF and CKD patients.
- Ivabradine showed lower risk of MACE, heart failure exacerbation, and all-cause mortality compared to digoxin.
- Retrospective cohort study with 3,140 matched patients (1,570 per group).
- Ivabradine associated with 26.8% MACE vs. 31.6% with digoxin (HR 0.79, p<0.001).
- Ivabradine reduced HFE risk (HR 0.83, p=0.015) and mortality (HR 0.69, p<0.001).
- Findings suggest ivabradine may be safer and more effective for HFrEF and CKD patients.