Reversible acetylation of Hpo regulates the Hippo pathway - PubMed
2 days ago
- #Hdac3
- #Hippo pathway
- #acetylation
- The Hippo pathway is crucial for regulating organ size and tissue homeostasis, with dysregulation linked to diseases like tumors.
- Hpo undergoes reversible acetylation by Nej (acetyltransferase) and Hdac3 (deacetylase), which regulates its stability.
- Loss of Hdac3 increases Hippo target gene expression, which can be rescued by overexpressing Wts, placing Hdac3 upstream of Wts.
- Only cytoplasmic Hdac3 interacts with Hpo to deacetylate and stabilize it, despite Hdac3's presence in both cytoplasm and nucleus.
- Knockdown of Nej reduces Hippo target gene expression, a phenotype reversible by silencing Hdac3.
- The study highlights the role of reversible acetylation in Hippo pathway regulation, offering insights into growth control and potential therapies.