Type 2 diabetes mellitus - PubMed
2 hours ago
- #diabetes
- #chronic disease
- #obesity
- Type 2 diabetes mellitus (T2DM) is a chronic, progressive disease influenced by genetic, biological, behavioral, and social factors.
- Increasing obesity rates have shifted T2DM epidemiology, with rising prevalence in younger individuals (early-onset T2DM).
- Early-onset T2DM is linked to aggressive disease progression, higher risk factors, and severe complications compared to later-onset T2DM.
- T2DM traditionally increases the risk of microvascular and macrovascular complications, though cardiovascular complications have decreased in some high-income countries.
- Emerging complications include mental health and cognitive function issues, with growing multimorbidity and reduced quality of life.
- Obesity prevalence has led to higher rates of obesity-related complications.
- Novel therapies and technologies offer benefits, but socioeconomic disparities may hinder equitable access.
- A person-centered, holistic approach is needed, integrating glucose and weight management with attention to comorbidities, psychosocial well-being, and social determinants of health.