New nanotherapy clears amyloid-β reversing Alzheimer's in mice
7 hours ago
- #Alzheimer's
- #Neuroscience
- #Nanotechnology
- Researchers developed bioactive nanoparticles that restore the blood-brain barrier (BBB) and clear toxic proteins, reversing Alzheimer’s symptoms in mice.
- The nanoparticles, called 'supramolecular drugs,' focus on repairing the BBB rather than targeting neurons directly.
- Restoring BBB function enabled the removal of amyloid-β (Aβ), a key protein in Alzheimer’s pathology.
- In mice, just three doses of the nanoparticles reduced Aβ by 50-60% within an hour and reversed cognitive decline.
- The nanoparticles mimic the LRP1 protein, which normally clears Aβ, restoring vascular function and natural clearance mechanisms.
- Behavioral tests showed mice treated with nanoparticles exhibited behavior similar to healthy mice, even at advanced ages.
- The study suggests a new therapeutic approach targeting vascular health to combat neurodegenerative diseases like Alzheimer’s.