Modified letrozole vs GnRH antagonist protocols in ovarian aging women for IVF: an open-label, multicenter, randomized controlled trial - PubMed
3 hours ago
- #IVF
- #ovarian aging
- #randomized controlled trial
- Study compares modified letrozole (mLP) vs GnRH antagonist protocols in women with diminished ovarian reserve or advanced age (40-45 years).
- 318 participants were randomized into two groups (mLP: 159, GnRH antagonist: 159) in a multicenter, open-label trial (2020-2023).
- Primary outcomes (cumulative clinical pregnancy rate and live birth rate) showed no significant difference between protocols.
- mLP showed significantly higher clinical pregnancy rates in fresh embryo transfers for women with diminished ovarian reserve (65.8% vs 36.4%).
- No significant differences in live birth rate, biochemical pregnancy loss, or miscarriage rates were observed between protocols.
- mLP may improve IVF efficacy for women with diminished ovarian reserve, particularly in fresh embryo transfers.