Predicting recurrence in patients with node-negative perihilar cholangiocarcinoma after an R0 resection - PubMed
5 hours ago
- #Recurrence prediction
- #Perihilar cholangiocarcinoma
- #KRAS mutation
- Study focuses on predicting recurrence in node-negative perihilar cholangiocarcinoma (pCCA) after R0 resection.
- Among 298 R0N0 pCCA patients, 44% experienced recurrence, highlighting the need for better risk stratification.
- Key predictors of inferior recurrence-free survival (RFS) include advanced AJCC T category, perineural invasion, and poor tumor differentiation.
- A pathology-based risk score categorized patients into low, intermediate, and high-risk groups with distinct RFS outcomes.
- KRAS mutations, found in 29% of profiled patients, were associated with significantly reduced RFS.
- The proposed risk score aims to guide adjuvant therapy and postoperative surveillance decisions.