Liver-directed AAV-IL-10 therapy enhances CD8+ T cell-mediated immunity against hepatocellular carcinoma - PubMed
4 hours ago
- #CD8+ T cells
- #HCC immunotherapy
- #AAV-IL-10 therapy
- Liver-directed AAV-IL-10 therapy reduces intrahepatic tumor burden in HCC mouse models.
- Treatment enhances CD8+ T cell infiltration and functional activation, including Trm-like phenotypes.
- Antitumor effects are liver-specific and overcome local immunosuppression without affecting distant tumors.