Engineered Exosomes Co-Delivering EGF and FGF Ameliorate Androgenetic Alopecia in a Mouse Model - PubMed
4 hours ago
- #hair regeneration
- #androgenetic alopecia
- #engineered exosomes
- Androgenetic alopecia (AGA) involves hair follicle miniaturization and growth factor deficiency.
- EGF and FGF are crucial for hair follicle regeneration but are downregulated in AGA.
- Engineered exosomes (EXO-EGF/FGF) were created using LAMP2B fusion technology to deliver EGF and FGF.
- EXO-EGF/FGF showed higher levels of EGF and FGF compared to natural exosomes.
- In vitro, EXO-EGF/FGF promoted proliferation and migration of human dermal papilla cells (HDPCs).
- In vivo, EXO-EGF/FGF restored hair density and follicle integrity in AGA mice without toxicity.
- The therapy reactivated the NOTCH signaling pathway and increased anagen-phase hair follicles.
- This approach offers a novel, safe, and clinically translatable treatment for AGA.