Efficacy and safety of acupuncture-related therapies in improving insulin resistance, reproductive endocrine outcomes, and ovarian morphology in polycystic ovary syndrome: a systematic review and netw

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Acupuncture-related therapies (ARTs) were evaluated for efficacy and safety in treating polycystic ovary syndrome (PCOS).
The study included 53 randomized controlled trials (RCTs) with 4,406 participants, comparing 12 ART regimens.
Key outcomes measured were improvements in insulin resistance (HOMA-IR), reproductive endocrine outcomes, and ovarian morphology.
Acupoint injection therapy (AIT) and acupuncture plus moxibustion (Acu + Moxi) significantly reduced HOMA-IR.
AIT, catgut implantation at acupoint (CIAA), and acupuncture (Acu) were effective in reducing fasting insulin (FINS).
Electroacupuncture (EA) reduced waist-to-hip ratio (WHR), and laser acupuncture (LA) reduced testosterone (T) and luteinizing hormone (LH).
Warm needle therapy (WNT) and Acu reduced antral follicle count (AFC), and Acu also reduced ovarian volume (OV).
Acupuncture ranked among the top interventions across multiple outcomes.
Most adverse events reported were non-serious and transient, indicating ARTs are safe complementary therapies for PCOS.

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