MiR-34a deficiency enhances nucleic acid sensing and type I IFN signaling in a mouse model of Alzheimer's disease - PubMed
a day ago
- #Alzheimer's disease
- #type I interferon
- #microglia
- MiR-34a deficiency enhances nucleic acid sensing and type I IFN signaling in Alzheimer's disease (AD) mouse models.
- Increased miR-34a levels in the brain are associated with AD, but its role in pathogenesis was unclear.
- MiR-34a knockout (KO) improved long-term memory in Tg-SwDI mice and altered Aβ42/Aβ40 ratios.
- Activated microglia increased in miR-34a KO mice, indicating enhanced neuroinflammation.
- RNA-seq revealed upregulation of type I interferon signaling pathways and interferon-stimulated genes (ISGs) in miR-34a KO mice.
- MiR-34a knockdown in microglia enhanced ISG expression upon TLR7 stimulation.
- Findings suggest miR-34a inhibits microglia transition to an interferon-responsive state, impacting synaptic and cognitive functions in neurodegeneration.