Glucuronolactone Promotes Mucin Sulfation to Alleviate Deoxynivalenol-Induced Intestinal Injury via Microbiota-Dependent and -Independent AHR Activation - PubMed
4 hours ago
- #AHR activation
- #intestinal health
- #mycotoxin
- Glucuronolactone (GLU) alleviates Deoxynivalenol (DON)-induced intestinal injury and inflammation in piglets.
- GLU promotes mucin sulfation, strengthening the intestinal mucus barrier via microbiota-dependent and independent pathways.
- Microbiota-dependent pathway involves increased probiotic Lactobacillus amylovorus and luminal indole-3-acetic acid.
- GLU directly enhances mucin sulfation independently of microbiota, both pathways activating aryl hydrocarbon receptor (AHR).
- AHR activation up-regulates sulfotransferase GAL3ST3, driving mucin sulfation and maintaining intestinal barrier homeostasis.
- Study identifies GLU as a potential nutritional intervention against DON-induced intestinal damage.