Acteoside targeting glutamine synthetase ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis - PubMed
3 hours ago
- #glutamine-synthetase
- #cardiotoxicity
- #ferroptosis
- Acteoside (ACT) is a bioactive compound that shows potential in treating doxorubicin-induced cardiotoxicity (DIC).
- Glutamine synthetase (GS) was identified as a key pathological driver in DIC through proteomic profiling.
- ACT was found to directly inhibit GS, preventing glutamate depletion and restoring the GLU-GSH-GPX4 antioxidant axis.
- By inhibiting GS, ACT suppresses lipid peroxidation and ferroptosis, both in vitro and in vivo.
- ACT administration significantly reduced DOX-induced cardiac dysfunction, fibrosis, and myocardial atrophy.
- The study suggests ACT as a promising natural compound for managing DIC by targeting ferroptosis.