Impact of vitamin D plasma levels on in vitro natural killer cell cytotoxicity against non-small cell lung carcinoma in the presence of nivolumab - PubMed
4 hours ago
- #Vitamin D
- #NSCLC Immunotherapy
- #NK Cell Cytotoxicity
- Vitamin D sufficiency correlates with enhanced NK cell cytotoxicity against NSCLC cells with high PD-L1 expression (HCC827) but not those with low PD-L1 (A549).
- This enhancement is most significant in male donors with serum vitamin D levels of at least 20 ng/mL, showing no additional benefit from higher levels.
- The study suggests adequate vitamin D could boost NK cell responses to PD-1 inhibitors like nivolumab in NSCLC, supporting its potential as an affordable adjunct to immunotherapy.