Jagged-mediated lateral induction patterns Notch3 signaling within adult neural stem cell populations - PubMed
3 hours ago
- #zebrafish
- #neural stem cells
- #Notch3 signaling
- Notch3 signaling promotes neural stem cell (NSC) quiescence and stemness in the adult brain.
- Nuclear translocation of Notch3 intracellular fragment (N3ICD) was measured in zebrafish adult telencephalon NSCs.
- Notch3 signaling levels correlate with NSC quiescence and stemness levels.
- High Notch3 signaling levels surround N3ICDlow cells, which express the deltaA (dla) ligand.
- Jagged1b (jag1b) ligand activates Notch3 signaling and sustains expression of the stemness factor Sox2.
- Lowering jag1b preserves the structured distribution of Notch3 signaling levels but reduces their variance.
- Notch3 signaling integrates Dla-mediated lateral inhibition and Jag1b-mediated lateral induction to control NSC quiescence and stemness dynamics.