Icaritin ameliorates mitochondrial dysfunction and autophagy impairment in cellular models of Alzheimer's disease - PubMed
3 hours ago
- #autophagy
- #mitochondrial dysfunction
- #Alzheimer's disease
- Icaritin (ICT) improves cell viability and reduces Aβ42 levels in Alzheimer's disease cellular models.
- ICT alleviates accumulation of phospho-Tau and phospho-TDP-43 proteins.
- ICT enhances mitochondrial function by improving morphology, reducing ROS, and increasing ATP production.
- ICT modulates AMPK/mTOR and PINK1/Parkin signaling pathways to improve autophagy impairment.