Targeting the PINK1/Parkin-FNDC5 pathway: a novel mechanism of icariin in regulating muscle-bone metabolic coupling in osteosarcopenia - PubMed
3 hours ago
- #osteosarcopenia
- #mitochondrial autophagy
- #icariin
- Icariin (ICA) from Epimedium targets the PINK1/Parkin-FNDC5 pathway to regulate muscle-bone metabolic coupling in osteosarcopenia (OS).
- A rat OS model was created using dexamethasone (DEX) and ovariectomy (OVX), showing significant bone and muscle decline, reversed by ICA intervention.
- ICA improved bone mineral density, muscle mass, and grip strength, while reducing inflammatory markers and increasing FNDC5 levels.
- Mechanistic studies showed ICA suppresses excessive mitochondrial autophagy and upregulates FNDC5 and osteogenic-related proteins.
- In vitro experiments confirmed ICA's role in modulating FNDC5 via the PINK1/Parkin pathway, supported by genetic evidence from SMR analysis.
- ICA's potential in treating postmenopausal osteosarcopenia is supported, though further validation is needed for other OS forms.