Neuroinflammation and Cellular Senescence in Brain Aging and Neurodegeneration - PubMed
5 days ago
- #neuroinflammation
- #brain aging
- #neurodegeneration
- Neuroinflammation is a core mechanism linking brain aging to cognitive decline.
- Chronic neuroinflammation involves cellular changes in microglia and astrocytes, leading to pro-inflammatory and neurotoxic phenotypes.
- Blood-brain barrier dysfunction, immune cell infiltration, and pathological protein aggregation exacerbate neuroinflammation.
- Key molecular pathways like NLRP3 inflammasome, NF-κB, and JAK/STAT are persistently activated.
- Six intervention strategies include modulating immune cells, inhibiting inflammatory pathways, targeting cytokines, using senolytics, enhancing anti-inflammatory defenses, and exploring natural products.
- Challenges include target specificity, blood-brain barrier delivery, individual heterogeneity, and clinical translation difficulties.
- Future research needs precise drug design, innovative delivery technologies, biomarker development, and interdisciplinary collaboration.