The Microglial Lactate-Lactylation Axis as a Metabolic-Epigenetic Driver of Alzheimer's Disease - PubMed
4 hours ago
- #Metabolic-Epigenetic Crosstalk
- #Alzheimer's Disease
- #Lactylation
- Central role of bioenergetic failure and metabolic-epigenetic crosstalk in Alzheimer's disease (AD) progression.
- Disrupted glucose metabolism, lactate build-up, and protein lactylation identified as key pathophysiological factors in AD.
- Microglial lactate-lactylation axis may shift from compensatory to maladaptive pro-inflammatory functions across AD stages.
- Hypothesis: microglia-derived lactate could contribute to neuronal tau lactylation via intercellular metabolic crosstalk.
- Future research should focus on glycolytic flux, epigenetic mechanisms, and therapeutic strategies targeting stage-specific lactylation.