Mitochondrial transfer to granulocytic myeloid-derived suppressor cells augments immunosuppressive activity - PubMed
a day ago
- #Staphylococcus aureus
- #immunosuppression
- #mitochondrial transfer
- Mitochondrial transfer from macrophages to G-MDSCs via tunneling nanotubes enhances their immunosuppressive activity.
- Increased mitochondrial abundance in G-MDSCs boosts their respiratory capacity and T cell-suppressive function.
- Enhanced G-MDSC activity reduces TNF and IL-6 production, promoting S. aureus biofilm persistence.
- In a mouse model, mitochondrial transfer from macrophages to G-MDSCs increased bacterial burden, reversible with non-functional mitochondria.
- The study highlights the role of mitochondria in augmenting G-MDSC anti-inflammatory properties in S. aureus infections.