Rhoifolin inhibits ferroptosis and alleviates pulmonary arterial hypertension via the TNF-α/TNF-R1/CASP8/CASP3 pathway - PubMed
4 hours ago
- #Flavonoid
- #Ferroptosis
- #Pulmonary Arterial Hypertension
- Rhoifolin (ROF), a natural flavonoid, alleviates pulmonary arterial hypertension (PAH) by inhibiting ferroptosis.
- The therapeutic effect is mediated through the TNF-α/TNF-R1/CASP8/CASP3 signaling pathway.
- Bioinformatics, molecular docking, and dynamics simulations predicted and validated ROF's stable binding to key targets.
- In vitro, ROF rescued pulmonary arterial smooth muscle cells from Erastin-induced ferroptosis.
- In vivo, ROF improved hemodynamics, reduced pulmonary ferroptosis markers, and restored anti-ferroptotic defenses in a PAH rat model.