NAMPT inhibition induces ferroptosis via mitochondrial metabolic reprogramming to enhance tumour immunogenicity in glioblastoma - PubMed
2 hours ago
- #ferroptosis
- #NAMPT inhibitor
- #glioblastoma
- NAMPT inhibition by GMX1778 induces ferroptosis in glioblastoma cells through mitochondrial metabolic reprogramming.
- Ferroptosis enhances tumour immunogenicity via ER stress activation, leading to increased calreticulin exposure, ATP release, and HMGB1 release.
- GMX1778-treated glioma cells promote macrophage polarization from M2 to M1 phenotype.
- In vivo, GMX1778 pre-treatment reduces tumour incidence and boosts anti-tumour immune responses in glioma-bearing mice.
- NAMPT inhibitors represent promising therapeutic agents for glioblastoma by linking metabolic targeting to immunogenic cell death.