Identification of tumor initiating cells and early marker genes in histologically normal colonic mucosa that lead to neoplastic transformation - PubMed
8 hours ago
- #Tumor-Initiating Cells
- #Single-Cell RNA-Seq
- #Colorectal Cancer
- Study identifies tumor-initiating cells (TICs) in histologically normal colonic mucosa that initiate neoplastic transformation.
- TICs exhibit enhanced stemness, early EMT, interferon signaling, and suppressed oxidative phosphorylation compared to normal stem-like cells.
- ETS2, SLC12A2, and LEFTY1 are TIC-specific markers; SOD3 and GPRC5A increase along the TIC-to-tumor stem-like trajectory.
- TIC-like cells are enriched in tubular adenomas but scarce in serrated lesions, supporting a stem-like expansion model for conventional adenomas.