Neural circuits for decision-making based on pineal photoreception in zebrafish - PubMed
10 hours ago
- #decision-making
- #neural circuits
- #pineal photoreception
- Zebrafish pineal organs have photosensitive cells using parapinopsin 1 (PP1), a bistable opsin, for chromatic responses to UV and visible light.
- Pineal ganglion cells show chromatic responses reliant on PP1, as evidenced by calcium imaging and reduced responses in PP1-deficient fish.
- The tegmentum in the brain receives pineal color information and also integrates indirect retinal input, influencing vertical movement decisions.
- PP1-deficient and tegmentum neuron-ablated fish display impaired vertical movements in response to wavelength changes, indicating the circuit's role in decision-making.
- The study provides insights into neural circuits combining pineal and retinal light information, and how PP1-based color processing affects behavior.