Interleukin 11-Induced MicroRNAs as Functional Mediators and Circulating Biomarkers of Cardiac Fibrosis - PubMed
3 hours ago
- #biomarkers
- #microRNAs
- #cardiac fibrosis
- Interleukin 11 (IL-11) induces cardiac fibrosis through microRNA dysregulation.
- MicroRNA-27b-5p and microRNA-497-5p identified as downstream effectors of IL-11 signaling.
- These microRNAs target HIF-1 signaling regulators Egln1 and Egln2.
- Increased microRNA levels correlate with severity of left ventricular fibrosis in aortic stenosis patients.
- Potential for microRNA-27b-5p and microRNA-497-5p as circulating biomarkers and therapeutic targets.