TRMT6-directed m1A modification initiates lung squamous cell carcinoma via YTHDF3-stabilized cell cycle genes - PubMed
12 hours ago
- #Lung cancer
- #RNA modification
- #Cell cycle
- TRMT6-directed m1A modification plays a key role in initiating lung squamous cell carcinoma (LUSC).
- TRMT6 is the most up-regulated m1A writer in LUSC and serves as a diagnostic biomarker.
- TRMT6 installs m1A marks on cell-cycle genes like TOPBP1 and DSN1, stabilizing them via YTHDF3.
- Site-specific m1A deposition on DSN1 mRNA modulates its expression and drives cancer proliferation.
- The study reveals a new m1A-dependent regulatory axis critical for LUSC diagnosis and progression.