Multimodal imaging reveals a lysosomal drug reservoir that drives heterogeneous distribution of PARP inhibitors - PubMed
3 hours ago
- #lysosomal sequestration
- #ovarian carcinoma
- #PARP inhibitors
- Multimodal imaging reveals heterogeneous distribution of PARP inhibitors in ovarian carcinoma.
- Lysosomal sequestration creates a drug reservoir affecting PARP inhibitor levels in the nucleus.
- Rucaparib and niraparib, but not olaparib, show altered intracellular levels with lysosomal perturbation.
- High-drug regions correlate with apoptotic and lysosomal signatures in spatial transcriptomics.
- Patient-derived explant models demonstrate variable PARP inhibitor accumulation between and within tumors.